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Uusimmat julkaisut

Do women shy away from risky skill games?
(Elsevier BV, 2023-05-16) Lambrecht, Marco; Oechssler, Joerg; Economics, Helsinki
A risky skill game is a game in which skill plays an important role but outcomes are also strongly influenced by random factors. Examples are poker or blackjack but also many economic activities like trading on financial markets. In an online experiment we let subjects choose how often they want to play a risky skill game. We find that women play only half as many rounds in risky skill games with high variance. In contrast, there is no gender difference if the outcomes depend exclusively on chance or (mostly) on skill. Our results indicate that previous research on gender effects in risky environments (such as tournaments) may have greater applicability than previously thought.
Targeting epigenetic and metabolic vulnerabilities in high-risk acute myeloid leukemia and myelodysplastic syndromes
(Helsingin yliopisto, 2026-06-18) Ikonen, Nemo; Tognon, Cristina; Helsingin yliopisto, lääketieteellinen tiedekunta; Helsingfors universitet, medicinska fakulteten; University of Helsinki, Faculty of Medicine; Heckman, Caroline; Vähä-Koskela, Markus
Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) are myeloid malignancies that are highly heterogeneous, which makes treatment challenging since every patient has a unique disease profile. In recent years, many novel treatments have been approved for the treatment of MDS and AML that target specific mutations or tumor related proteins, as our understanding of disease pathogenesis has increased. However, many sub-groups of patients still lack effective treatments, particularly those patients with high-risk MDS and AML, where the treatment has not changed much for over a decade. In study I, we aimed to identify a novel treatment for AML patients with chromosomal aberrations monosomy 7 or deletion 7q (-7/-7q). Through ex vivo drug sensitivity screening, we discovered that samples with -7/-7q were more sensitive to nicotinamide phosphoribosyltransferase (NAMPT) inhibition compared to non -7/-7q samples. We confirmed this result by using multiple orthogonal assays and showed that the effect was dependent on the loss of one copy of the NAMPT gene. Our analysis of bulk and single cell gene expression data indicated that samples with -7/-7q have a NAMPT haploinsufficient gene expression profile, which would explain the increased sensitivity. Additionally, we explored the drug combination of NAMPT and BCL2 inhibitors as an alternative strategy to target the CD34+CD38- leukemic cell population in -7/-7q. In study II, we assessed whether MDS patients with -7/-7q would also benefit from NAMPT inhibition. Using a similar ex vivo drug sensitivity screening approach, we confirmed that MDS samples are similarly sensitive to NAMPT inhibition as AML samples. Importantly, we showed that MDS samples with -7/-7q were more sensitive to NAMPT inhibition compared to non -7/-7q MDS samples. Gene expression analysis confirmed that MDS samples also exhibit a haploinsufficient NAMPT gene expression profile. Finally, we investigated NAMPT inhibitors in combination with other clinically relevant inhibitors. In study III, we explored a drug combination of LSD1 and GSK3 inhibition as a novel differentiation therapy for AML. We showed that the combination synergistically induced differentiation, reduced proliferation, and clonal capacity in AML cell lines and patient samples. Additionally, the combination reduced tumor burden and expanded the lifespan in in vivo models. We also identified DNMT3A mutations as a possible marker of sensitivity for the treatment, and assessed the clinical relevance of our findings in a publicly available data set. In summary, this research has identified two promising novel treatments for AML and MDS patients: First, we demonstrated that AML and MDS with -7/-7q are highly sensitive to NAMPT inhibition, suggesting that NAMPT inhibitors could be a novel targeted treatment for these patients. Second, we showed that LSD1 and GSK3 inhibition is highly synergistic at promoting differentiation in AML.
In search of compassionate mindset – awakening compassion in organizations
(Helsingin yliopisto, 2026-06-05) Paakkanen, Miia; Kaltiainen, Janne; Helsingin yliopisto, teologinen tiedekunta; Helsingfors universitet, teologiska fakulteten; University of Helsinki, Faculty of Theology; Pessi, Anne Birgitta; Martela, Frank
This study explores how compassion can be awakened and cultivated in organizations. The study aims to understand the question from three different perspectives: teaching compassion, identifying and battling barriers to it, and better understanding its parallel and potentially synergetic process of responding to validate others’ positive emotions at work. While compassion has been recognized as a fundamental human need – also at work – and shown to positively impact both employee well-being and organizational performance in many ways, the means to increase it in organizational settings have gained less attention. As the modern working environment is characterized by intensifying competition, urgency, and increasing uncertainty, with high costs to employees’ mental well- being and organizations’ retention and learning capabilities, the need to cultivate compassion is more pressing than ever. The data for this research were collected through two large-scale empirical studies and one theoretical exploration. The first empirical study presents a quasi- randomized controlled field intervention of a new in-depth compassion-infusing emotional skills cultivation training that was repeated with seven groups of managers in five different organizations. Data were collected from managers (N = 68 and 90) and their followers (N = 85 and 72) of both participant and control groups through self-reported questionnaires in two waves: a week before and a week after the intervention. Data analysis was run with SPSS using a 2x2 (group, time) repeated-measures analysis of variance (ANOVA). The second empirical study explored the barriers to compassion in organizations through 14 thematic focus group interviews with a total of 81 informants from five different organizations. The analysis was data-determined content analysis, assisted by Atlas.ti qualitative analysis software. The third study of this research explored theoretically the steps and the potential mechanisms and benefits of the parallel process of compassion, namely, the social process of responding to validate coworkers’ positive emotional experiences at work. Together, the three studies opened up new perspectives to the means of awakening compassion in organizations. The findings of this study – drawn from a synthesis of the three published individual articles – uncover that compassion in organizations can be increased, which is known to be beneficial for the organization. More specifically, the findings unravel three potential pathways to awaken compassion in organizations: teaching compassion through emotional skills; identifying and addressing the barriers standing in the way of compassion; and expanding the understanding of positive responding to validate others’ emotions. Firstly, to support the three pathways, this study introduces a new emotional skills training designed and tested to improve compassion through improving emotional skills, develops a new emotional skills measure to assess the level of emotional skills, and demonstrates the link between emotional skills and workplace compassion for the first time. Secondly, the findings identify a list of barriers to compassion in five key organizational dimensions: mindset, behavior, culture, structure, and leadership. The findings also recognize interlinks between these barriers, suggesting that they ought to be addressed with systems intelligence. The findings further identify the five key barriers for managers to battle. Thirdly, this thesis introduces a new concept of a validating response, as the parallel process to compassion, explaining the steps and mechanisms as well as potential outcomes of responding to validate others’ positive emotional experiences. Moreover, this study associates the validating response as an important building block of such interpersonal phenomena at work as psychological safety, high-quality connections, and capitalization of positive emotions, and recognizes both compassion and the validating response as parallel affirmative processes and positive responses to others’ emotional experiences, opening up a discussion of their potential synergy. Present in all three pathways, this thesis highlights and discusses the multifaceted role that human relationality plays in terms of awakening compassion. The study further introduces a new three-part concept of a compassionate mindset, deeply rooted in human relationality, as a key attitude of a leader with which to ignite the inherent potential of any human system, such as an organization, to drive positive change in terms of awakening compassion. Moreover, it advances theory by extending the understanding of compassion as a motivational, preventive, and self-directed process; by conceptualizing the validating response as a relational antecedent to compassion; and by offering a systemic perspective on barriers to compassion within organizations. It also contributes methodologically through the development and testing of a novel compassion-focused emotional skills intervention. Finally, the findings highlight that actively committing to have the difficult conversations compassionately is an important part of compassion and that recognizing and validating what is important and meaningful to the other person, without imposing subjective judgments of value or emotional valence, is essential in terms of awakening compassion.
A from-the-top view of strategic flexibility: a study of CEO social class, TMT regulatory focus, and environment uncertainty
(Springer, 2025-05-13) Yang, Man; Liu, Heng; Zhao, Hanqing; Wincent, Joakim; Management and Organisation, Vaasa; Entrepreneurship, Management and Organisation, Helsinki
Strategic flexibility is the key to navigating turbulent and complex times, yet its managerial antecedents lack adequate examinations. With interest in testing an explanation from the ‘strategic fit’ paradigm, where the top management is the key, we develop a new theory integrating CEO, TMT, and environmental attributes. We propose that the CEO’s social class is an important contextual factor that influences the effects of TMT posture in terms of two types of regulatory focus on firm strategic flexibility, which is further contingent upon different environmental conditions. The empirical findings from two studies support the prominent role of CEO social class in the relationships between TMT promotion/prevention focus and firm strategic flexibility. Moreover, the moderation effects of CEO social class are stronger when the firm faces higher market or regulatory uncertainty, a typical situation faced by firms in the Asia Pacific. Our study highlights that the interaction of the CEO’s social status and the TMT’s regulatory focus is important to understand if and how firms are executing strategic flexibility in turbulent times.
Tämäonoikeinpitkäsanaotsikossa
(Helsingin yliopisto, 2026-05-07) Matlu, Matta; Helsingin yliopisto, Matemaattis-luonnontieteellinen tiedekunta; University of Helsinki, Faculty of Science; Helsingfors universitet, Matematisk-naturvetenskapliga fakulteten
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Testataan tikettiä ETHESIS2-630
(Helsingin yliopisto, 2026-05-07) Kasvis, Kaaro; Helsingin yliopisto, Kasvatustieteellinen tiedekunta; University of Helsinki, Faculty of Educational Sciences; Helsingfors universitet, Pedagogiska fakulteten
Testataan tikettiä ETHESIS2-630Testataan tikettiä ETHESIS2-630Testataan tikettiä ETHESIS2-630Testataan tikettiä ETHESIS2-630Testataan tikettiä ETHESIS2-630
Testi-oppimateriaali
(Helsingin yliopisto, Kasvatustieteellinen tiedekunta, 2025) Xuuu, Xaa; Helsingin yliopisto
Matlun testiväitös
(Helsingin yliopisto, 2026) Testaaja, Kata; Helsingin yliopisto
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Sed pulvinar leo in nunc accumsan, at eleifend eros ultrices. In sem felis, interdum sit amet fringilla scelerisque, commodo in magna. Nulla condimentum, velit a maximus iaculis, neque odio condimentum dui, nec ultrices orci diam vel erat. Sed finibus tellus quis neque facilisis eleifend. Suspendisse non commodo quam, et vestibulum ante. Praesent eu mattis ligula, eget tempus massa. Praesent tempor vitae risus vel bibendum.
testataan Tomin kanssa : jippii
(Helsingin yliopisto, 2026-04-28) Kasvis, Kaaro; Helsingin yliopisto, Kasvatustieteellinen tiedekunta; University of Helsinki, Faculty of Educational Sciences; Helsingfors universitet, Pedagogiska fakulteten
Oppiminen on tietojen, taitojen ja tapojen omaksumista. Oppiminen voi tapahtua joko opiskelemalla, opettelemalla tai harjoittelemalla, tai kokemuksen, esimerkin tai ympäristön vaikutuksen kautta.[1] Behavioristisesti käsitettynä oppiminen tarkoittaa käyttäytymisessä havaittavia pysyviä muutoksia, jotka syntyvät pääasiassa olion ja ympäristön vuorovaikutuksessa.[2] Oppimiskäsityksiä on erilaisia. Oppiminen voidaan nähdä ihmisen kehittymisenä ylipäätään. Tällöin oppiminen ei tarkoita pelkästään pysyviä muutoksia käyttäytymisessä, vaan myös pysyvyyttä tai hetkellisiä muutoksia. Psykologiassa oppiminen tarkoittaa yleensä ihmisen tai eläimen oppimista, didaktiikassa taas oppimista tarkastellaan nimenomaan opetuksen näkökulmasta. Muilla tieteenaloilla puhutaan oppivista dataohjelmista, oppivista organisaatioista ja oppivista alueista. Perustasollaan yksilön oppiminen edellyttää muistia ja aistitoimintaa. Oppimista tapahtuu lähes aina kun ihminen vertailee tapahtunutta ja aiottua toimintaa (palaute) tai tapahtunutta ja aiempaa toimintaa (oppiminen kokemuksesta). Oppimistapoja on hyvin erilaisia, koska eri tilanteisiin soveltuvat erilaiset oppimisen menetelmät, ja koska oppijoissa on yksilöllisiä eroja.
Traceability in luxury : Harnessing B2B relationships to enhance ethical practices in the luxury industry
(Elsevier Inc., 2023-05) Holmqvist, Jonas; Kowalkowski, Christian; CERS - Centre for Relationship Marketing and Service Management, Helsinki; Marketing, Helsinki
The luxury industry is a rapidly growing sector, with several luxury conglomerates among the world's largest companies. This growth is reflected in the increasing number of studies on luxury research. However, most existing research focuses only on the consumer perspective and overlooks the potential of B2B relationships in the luxury industry. This paper addresses this research gap by developing how strong B2B relationships are crucial to an emerging key topic in luxury, namely traceability. Specifically, we highlight the growing significance of traceability in luxury supply chains and explain how it elevates the relevance of B2B relationships. We further identify a dual purpose for traceability in luxury: it showcases ethical practices to customers and highlights areas for improvement. We present seven research propositions for luxury companies to improve ethical practices and enhance traceability through their B2B relationships. Integrating extant research with managerial insights, we highlight the importance of two new perspectives—managerial practices and B2B relationships—as key cornerstones to understanding and improving business ethics in the luxury industry.